Energy

5-Amino-1MQ A synthetic small molecule studied as an inhibitor of NNMT, an enzyme implicated in obesity and metabolic dysregulation, with additional research in aged muscle regeneration. View research notes → MOTS-c A peptide encoded within mitochondrial DNA, studied as a regulator of metabolic homeostasis and an exercise mimetic with potential relevance to aging and insulin sensitivity. View research notes → NAD+ One of the most-studied molecules in longevity science. NAD+ is a coenzyme rather than a peptide, but is widely tracked alongside research peptides for its role in aging, cellular repair, and metabolic function. View research notes → NAD+ vs. 5-Amino-1MQ, which one you actually want Both get sold in the energy aisle and they do almost nothing alike. One is a molecule you're running low on, the other blocks an enzyme that gets in the way, and that difference decides whether you take it every week or a few months a year. Read → SS-31 (Elamipretide) SS-31, also known as elamipretide or MTP-131, is a mitochondria-targeted tetrapeptide that homes to the inner mitochondrial membrane and stabilizes cardiolipin. Research spans cardiac aging, hypertensive cardiomyopathy, and skeletal muscle decline. View research notes → Urolithin A A gut-microbiome metabolite of ellagitannins, studied for its effect on mitophagy, the process by which cells clear damaged mitochondria. Not a peptide, and sold as an oral supplement rather than by the milligram. View research notes → What to Take With NAD+, and What to Take First Every thread about NAD+ ends with someone telling you to pair it with something. Here's which pairings have a reason behind them, which are just enthusiasm, and why the order matters more than the combination. Read → Why Retatrutide Is Making You So Tired, and What Actually Helps If retatrutide has you flat by midafternoon, you're not imagining it, and it's almost never just one thing. Here's what's actually driving it and what helps while your body catches up. Read →