ARA-290 dosage chart for a 28-day course
The two published studies that dosed ARA-290 daily under the skin used 4 mg for 28 days. Vendor pages often run 1 to 2 mg a day instead, and the one study that tested 1 mg saw no clear change in its main measure.
How much ARA-290 (Cibinetide) do people take?
Amount
4 mga dayTiming
Once a dayevery day of the courseCourse
28 daysthe length the studies usedRoute
Under the skininjectionAmount, timing and course are what two published human studies used: a 28-day study in adults with sarcoidosis-related nerve damage (1, 4 and 8 mg a day tested) and a 28-day study in adults with type 2 diabetes and painful nerve damage (4 mg a day, under the skin). Neither study set a repeat schedule.
ARA-290 (Cibinetide) dosage chart
How to read the ARA-290 chart
The first three rows come from human studies, so they're the amounts with something behind them. The last row is what vendor pages describe, with no study behind it. Background on what ARA-290 is lives on the ARA-290 page.
ARA-290 injection dosage and mixing
ARA-290 comes as a freeze-dried powder for injection under the skin. You mix it with bacteriostatic water, which is sterile water with a preservative so one vial can be drawn from more than once. The tables cover 10 mg and 16 mg vials, and a 16 mg vial holds exactly four 4 mg doses. They show the units to draw on a U-100 syringe, which holds 100 units in 1 mL, for 1, 2 and 3 mL of water.
| Water | Strength | 1 mg | 2 mg | 4 mg |
|---|---|---|---|---|
| 1 mL | 16,000 mcg per mL | 6.3 units | 12.5 units | 25 units |
| 2 mL | 8,000 mcg per mL | 12.5 units | 25 units | 50 units |
| 3 mL | about 5,333 mcg per mL | 18.8 units | 37.5 units | 75 units |
| Water | Strength | 1 mg | 2 mg | 4 mg |
|---|---|---|---|---|
| 1 mL | 10,000 mcg per mL | 10 units | 20 units | 40 units |
| 2 mL | 5,000 mcg per mL | 20 units | 40 units | 80 units |
| 3 mL | about 3,333 mcg per mL | 30 units | 60 units | 120 units, more than one syringe |
Amounts are rounded to the nearest tenth of a unit, and a syringe reads to about the nearest unit. Rows over 100 units take two draws, so 1 or 2 mL of water is the easier choice for the 4 mg dose.
For any other vial, water or amount, the reconstitution calculator does the same math.
When and how often
Once a day. Both studies dosed once a day, the diabetes study by self-injection under the skin, and nothing we found sets a time of day.
Twenty-eight days. That's the length of both studies. Neither set a repeat course, and the diabetes study followed people for one more month without treatment.
For planning, 4 mg a day for 28 days is 112 mg in all, and 1 to 2 mg a day for 28 days is 28 to 56 mg. Compare vendors on price per milligram against the whole course, not on the price of one vial.
How long a vial lasts
A mixed vial goes on a 28-day clock in the fridge the day water goes in, however much of it gets used. At 4 mg a day, a 16 mg vial lasts 4 days and a 10 mg vial gives 2 whole doses with 2 mg left over, so the clock never matters. For a 112 mg course that's seven 16 mg vials with nothing left over, or 14 10 mg vials if each is used for two whole doses and the leftover isn't pooled. At 1 mg a day a 16 mg vial lasts 16 days and a 10 mg vial lasts 10, and at 2 mg a day they last 8 days and 5.
Signs the amount or timing is off
These are reported experiences, not findings from a study of research vials.
Redness or soreness where you injected. People report it with any daily injection, and they rotate the spot each day.
No change after 28 days. The studies measured at the end of the course, so people judge it then. No study supports a higher amount as the next step.
Cloudy or discolored liquid. A mixed vial that was clear and has turned cloudy or changed color is generally discarded rather than used.
It's sold for research. The human studies behind it are small and short, and the company that makes the drug took part in them.
Questions people ask about ARA-290 (Cibinetide) dosage
How much ARA-290 should I take per day?
Two human studies used 4 mg once a day under the skin for 28 days. Vendor pages often give 1 to 2 mg a day, and nothing we found sets 2 mg. The sarcoidosis study tested 1 mg and saw no clear change in nerve fiber area.
Should I go higher than 4 mg if it does nothing?
No study or label sets a higher amount after a month. The sarcoidosis study tested 8 mg a day, and that group's nerve fiber change was smaller than the 4 mg group's and not clear enough to count.
How much bacteriostatic water for a 16 mg vial of ARA-290?
You can use 1, 2 or 3 mL, because the water only changes the size of each draw. With 2 mL, a 4 mg dose is 50 units on a U-100 syringe and 2 mg is 25 units. A 10 mg vial with 2 mL gives 80 units for 4 mg.
Can you repeat ARA-290 after 28 days?
No study or label sets a repeat course or a longer run. The studies ran 28 days, and the type 2 diabetes study followed people for one more month without treatment.
Has ARA-290 been tested for diabetic nerve pain?
Yes, in one study of adults with type 2 diabetes and painful nerve damage, using 4 mg a day for 28 days. Symptom scores improved on a questionnaire, and the study called for more research.
How long does a mixed ARA-290 vial last?
A mixed vial is good for 28 days in the fridge. At every amount in the chart a 16 mg vial is gone in 16 days or less, so the 28 days doesn't come into play.
Where to buy ARA-290 (Cibinetide)
The five lowest per-mg prices in this morning's check, one listing per vendor.
- Evolve BioPep 16 mg · $39.99 $2.50/mg
- Peptide Crafters 16 mg · $45.00 $2.81/mg
- Double R Labs 40 mg · $119.99 $3.00/mg
- Oros Research 32 mg · $109.99 $3.44/mg
- GhostLabz 10 mg · $34.99 $3.50/mg
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