:root {
  --bg: #f5f7fa;
  --surface: #ffffff;
  --surface2: #f1f3f8;
  --border: #dee2ee;
  --accent: #6366f1;
  --accent-dark: #4f51c8;
  --accent-soft: rgba(99, 102, 241, 0.08);
  --accent-tag: rgba(99, 102, 241, 0.12);
  --text: #111827;
  --muted: #6b7280;
  --link: #6366f1;
  --approved-bg: #f0fdf4;
  --approved-border: rgba(22, 163, 74, 0.3);
  --approved-text: #166534;
  --disclaimer: #92400e;
  --disclaimer-bg: #fef3c7;
  --disclaimer-border: rgba(217, 119, 6, 0.3);
  --shadow: 0 1px 3px rgba(17, 24, 39, 0.06), 0 4px 12px rgba(17, 24, 39, 0.04);
  --shadow-hover: 0 4px 16px rgba(17, 24, 39, 0.10);
  --radius: 10px;
  --radius-sm: 6px;
}

*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }

body {
  font-family: 'Switzer', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
  font-size: 0.9375rem;
  line-height: 1.7;
  color: var(--text);
  background: var(--bg);
}

a { color: var(--link); text-decoration: none; }
a:hover { text-decoration: underline; }
img { display: block; max-width: 100%; }

.site-wrap {
  max-width: 860px;
  margin: 0 auto;
  padding: 0 24px 80px;
}

.site-main {
  padding-top: 0;
}

.site-header {
  background: var(--surface);
  border-bottom: 1px solid var(--border);
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 0 24px;
  height: 78px;
  position: sticky;
  top: 0;
  z-index: 100;
}

.site-header a.logo {
  display: flex;
  align-items: center;
  gap: 10px;
  text-decoration: none;
}

.site-header .logo img { height: 54px; width: auto; }

.site-header nav,
.site-footer nav {
  display: flex;
  gap: 24px;
  align-items: center;
}

.site-header nav a,
.site-footer a {
  font-size: 0.8125rem;
  font-weight: 600;
  color: var(--muted);
  letter-spacing: 0.04em;
}

.site-header nav a:hover,
.site-footer a:hover {
  color: var(--accent);
  text-decoration: none;
}

.btn-launch {
  background: var(--accent);
  color: #fff !important;
  font-size: 0.8125rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  padding: 8px 18px;
  border-radius: var(--radius-sm);
  text-decoration: none;
  transition: background 0.15s;
}

.btn-launch:hover { background: var(--accent-dark); }

.breadcrumb {
  display: flex;
  align-items: center;
  gap: 8px;
  font-size: 0.8125rem;
  color: var(--muted);
  padding: 14px 0;
  margin-bottom: 0;
}

.breadcrumb a { color: var(--muted); }
.breadcrumb a:hover { color: var(--accent); }

.article-header { margin-bottom: 40px; }
.article-meta { font-size: 0.8125rem; color: var(--muted); margin-bottom: 12px; }
.article-header h1 {
  font-size: clamp(1.6rem, 4vw, 2.25rem);
  font-weight: 800;
  line-height: 1.2;
  color: var(--text);
  margin-bottom: 14px;
}
.lede {
  font-size: 1.0625rem;
  color: var(--muted);
  line-height: 1.6;
  max-width: 620px;
}

.article-body { max-width: 680px; }
.article-body h2 {
  font-size: 1.125rem;
  font-weight: 700;
  color: var(--text);
  margin: 36px 0 14px;
  padding-bottom: 10px;
  border-bottom: 1px solid var(--border);
}
.article-body h3 { font-size: 0.9375rem; font-weight: 700; color: var(--text); margin: 24px 0 10px; }
.article-body p,
.article-body ul,
.article-body ol { color: var(--text); margin-bottom: 16px; line-height: 1.75; }
.article-body ul,
.article-body ol { padding-left: 22px; }

.content-section,
.bibliography,
.related-section,
.intro-section,
.research-area {
  margin: 36px 0;
}

.content-section:first-child,
.intro-section:first-child,
.research-area:first-child {
  margin-top: 0;
}

.section-heading {
  font-size: 1.125rem;
  font-weight: 700;
  color: var(--text);
  margin: 0 0 14px;
  padding-bottom: 10px;
  border-bottom: 1px solid var(--border);
}

.area-desc {
  color: var(--muted);
  margin-bottom: 18px;
}

.research-list,
.ref-list {
  display: grid;
  gap: 14px;
  padding-left: 0 !important;
  list-style: none;
}

.research-list li,
.ref-list li {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius-sm);
  padding: 16px 18px;
  box-shadow: var(--shadow);
}

.research-list strong {
  display: block;
  margin-bottom: 6px;
}

.research-list span,
.ref-text {
  color: var(--text);
  line-height: 1.65;
}

.ref-num {
  display: inline-block;
  min-width: 32px;
  font-weight: 800;
  color: var(--accent);
}

.cite {
  font-weight: 700;
  color: var(--accent);
}

.params-table-wrap {
  overflow-x: auto;
}

.params-table,
.price-table,
.comparison-table,
.mechanism-table {
  width: 100%;
  border-collapse: collapse;
  margin: 18px 0 24px;
  font-size: 0.875rem;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius-sm);
  overflow: hidden;
  box-shadow: var(--shadow);
}

.params-table th,
.params-table td,
.price-table th,
.price-table td,
.comparison-table th,
.comparison-table td,
.mechanism-table th,
.mechanism-table td {
  padding: 12px 14px;
  border-bottom: 1px solid var(--border);
  text-align: left;
  vertical-align: top;
}

.params-table th,
.price-table th,
.comparison-table th,
.mechanism-table th {
  background: var(--surface2);
  font-size: 0.75rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--muted);
}

.params-table tr:last-child td,
.price-table tr:last-child td,
.comparison-table tr:last-child td,
.mechanism-table tr:last-child td {
  border-bottom: 0;
}

.compound-grid,
.peptide-cards {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(240px, 1fr));
  gap: 16px;
  margin: 24px 0 32px;
}

.compound-card,
.peptide-card,
.cost-card,
.price-cta,
.fda-callout,
.approval-callout,
.note-box {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
}

.compound-card,
.peptide-card,
.cost-card {
  padding: 20px;
}

.compound-name,
.card-name {
  font-size: 1rem;
  font-weight: 800;
  color: var(--text);
  margin-bottom: 4px;
}

.compound-alias,
.card-desc,
.cost-note,
.price-note,
.cta-desc {
  color: var(--muted);
  font-size: 0.875rem;
  line-height: 1.55;
}

.stat-row {
  display: flex;
  justify-content: space-between;
  gap: 14px;
  border-top: 1px solid var(--border);
  padding: 10px 0;
}

.stat-row:first-of-type {
  margin-top: 14px;
}

.stat-label,
.cost-label,
.price-label,
.cta-label {
  font-size: 0.6875rem;
  font-weight: 800;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--muted);
}

.stat-value,
.cost-range,
.price-range {
  font-weight: 800;
  color: var(--text);
}

.price-range,
.cost-range {
  font-size: 1.35rem;
  margin: 4px 0;
}

.price-cta,
.fda-callout,
.approval-callout,
.note-box {
  padding: 18px 20px;
  margin: 24px 0;
}

.price-cta {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 18px;
  flex-wrap: wrap;
  border-left: 4px solid var(--accent);
}

.fda-callout,
.approval-callout {
  background: var(--accent-soft);
  border-color: rgba(99, 102, 241, 0.24);
}

.note-box {
  background: var(--surface2);
  color: var(--muted);
}

.btn-notes,
.btn-price,
.btn-calc,
.btn-card,
.btn-cta {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  margin-top: 14px;
  background: var(--accent);
  color: #fff !important;
  border-radius: var(--radius-sm);
  padding: 9px 14px;
  font-size: 0.8125rem;
  font-weight: 800;
  text-decoration: none;
}

.btn-notes:hover,
.btn-price:hover,
.btn-calc:hover,
.btn-card:hover,
.btn-cta:hover {
  background: var(--accent-dark);
  text-decoration: none;
}

.btn-card-muted {
  display: inline-flex;
  margin-top: 14px;
  color: var(--muted);
  font-size: 0.8125rem;
  font-weight: 700;
}

.badge {
  display: inline-flex;
  align-items: center;
  margin-left: 8px;
  border-radius: 999px;
  padding: 2px 8px;
  font-size: 0.625rem;
  font-weight: 800;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  background: var(--surface2);
  color: var(--muted);
}

.badge-live,
.badge-fda {
  background: rgba(16, 185, 129, 0.12);
  color: #047857;
}

.badge-soon {
  background: rgba(245, 158, 11, 0.14);
  color: #92400e;
}

.related-links {
  display: grid;
  gap: 10px;
}

.related-link {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius-sm);
  padding: 14px 16px;
  box-shadow: var(--shadow);
}

.related-link:hover {
  border-color: var(--accent);
  box-shadow: var(--shadow-hover);
  text-decoration: none;
}

.arrow {
  color: var(--muted);
  font-weight: 800;
}

.tags {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  margin-bottom: 16px;
}

.tag {
  display: inline-block;
  font-size: 0.6875rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  background: var(--accent-tag);
  color: var(--accent);
  padding: 3px 10px;
  border-radius: 20px;
  text-decoration: none;
}

.tag:hover {
  background: var(--accent);
  color: #fff;
}

.stats-bar {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 12px;
  margin-bottom: 48px;
}

.stat-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius-sm);
  padding: 14px 16px;
  box-shadow: var(--shadow);
}

.stat-card span {
  display: block;
  font-size: 0.6875rem;
  font-weight: 700;
  color: var(--muted);
  letter-spacing: 0.08em;
  text-transform: uppercase;
  margin-bottom: 4px;
}

.stat-card strong {
  display: block;
  font-size: 0.9375rem;
  color: var(--text);
}

.stat-card small {
  display: block;
  margin-top: 6px;
  font-size: 0.75rem;
  line-height: 1.45;
  color: var(--muted);
}

.callout,
.disclaimer {
  border-radius: var(--radius-sm);
  padding: 14px 18px;
  font-size: 0.8125rem;
  line-height: 1.6;
  margin: 32px 0;
}

.callout {
  background: var(--accent-soft);
  border: 1px solid rgba(99, 102, 241, 0.2);
  color: var(--text);
}

.disclaimer {
  background: var(--disclaimer-bg);
  border: 1px solid var(--disclaimer-border);
  color: var(--disclaimer);
}

.site-footer {
  border-top: 1px solid var(--border);
  padding: 32px 0 0;
  margin-top: 64px;
  font-size: 0.8125rem;
  color: var(--muted);
  display: flex;
  align-items: center;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 12px;
}

.home-hero {
  padding: 56px 0 36px;
  text-align: center;
}

.home-hero h1 {
  font-size: clamp(2rem, 5vw, 3rem);
  font-weight: 900;
  line-height: 1.15;
  color: var(--text);
  margin-bottom: 16px;
}

.home-hero .lede {
  margin: 0 auto 24px;
}

.microcopy {
  margin-top: 14px;
  font-size: 0.8125rem;
  color: var(--muted);
}

.steps-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(190px, 1fr));
  gap: 16px;
  margin-top: 22px;
}

.step-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 20px;
  box-shadow: var(--shadow);
}

.step-num {
  width: 30px;
  height: 30px;
  background: var(--accent);
  color: #fff;
  border-radius: 50%;
  display: flex;
  align-items: center;
  justify-content: center;
  font-weight: 800;
  font-size: 0.8125rem;
  margin-bottom: 12px;
}

.step-card h3,
.faq-item h3 {
  font-size: 0.9375rem;
  font-weight: 800;
  margin-bottom: 6px;
}

.step-card p,
.faq-item p {
  font-size: 0.875rem;
  color: var(--muted);
  margin: 0;
}

.faq-list {
  display: grid;
  gap: 16px;
}

.faq-item {
  border-bottom: 1px solid var(--border);
  padding-bottom: 16px;
}

.tag-grid,
.note-grid,
.vendor-grid {
  display: grid;
  gap: 16px;
}

.tag-grid,
.vendor-grid {
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
}

.tag-grid {
  margin-bottom: 64px;
}

.note-grid {
  grid-template-columns: repeat(auto-fill, minmax(150px, 1fr));
  margin-bottom: 32px;
}

.peptide-index-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(150px, 1fr));
  gap: 12px;
  margin-bottom: 32px;
}

.peptide-index-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 16px;
  min-height: 58px;
  display: flex;
  align-items: center;
  justify-content: center;
  text-align: center;
  font-weight: 700;
  font-size: 0.875rem;
  line-height: 1.25;
  color: var(--accent);
  text-decoration: none;
  transition: border-color 0.15s, background 0.15s, color 0.15s;
}

.peptide-index-card:hover {
  border-color: var(--accent);
  background: #f0f1ff;
  color: var(--accent-dark);
  text-decoration: none;
}

.peptides-page .peptide-index-grid {
  margin-top: 28px;
}

.peptides-page .peptide-index-card {
  min-height: auto;
  background: transparent;
  font-size: 0.875rem;
  font-weight: 600;
}

.peptides-page .peptide-index-card:hover {
  background: #f0f1ff;
}

.tag-card,
.note-card,
.vendor-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
  color: var(--text);
  text-decoration: none;
}

.note-card {
  display: flex;
  align-items: center;
  justify-content: center;
  min-height: 62px;
  padding: 14px 16px;
  text-align: center;
}

.tag-card {
  display: flex;
  flex-direction: column;
  gap: 8px;
  padding: 20px 22px;
  min-height: 176px;
}

.tag-card:hover,
.note-card:hover,
.vendor-card:hover {
  border-color: var(--accent);
  box-shadow: var(--shadow-hover);
  text-decoration: none;
}

.tag-card-name,
.note-card-name {
  font-size: 0.875rem;
  font-weight: 700;
  color: var(--text);
}

.tag-card-desc,
.note-card-desc {
  font-size: 0.8125rem;
  line-height: 1.5;
  color: var(--muted);
}

.tag-card-count,
.note-card-arrow {
  font-size: 0.75rem;
  font-weight: 700;
  color: var(--accent);
  margin-top: auto;
  padding-top: 4px;
}

.note-card-desc,
.note-card-arrow {
  display: none;
}

.tag-note-list {
  display: flex;
  flex-direction: column;
  gap: 14px;
  margin-bottom: 64px;
}

.tag-note-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 20px 24px;
  text-decoration: none;
  color: var(--text);
  box-shadow: var(--shadow);
  transition: box-shadow 0.18s, border-color 0.18s;
  display: flex;
  flex-direction: column;
  gap: 6px;
}

.tag-note-card:hover {
  box-shadow: var(--shadow-hover);
  border-color: var(--accent);
  text-decoration: none;
}

.tag-note-card-name {
  font-size: 1rem;
  font-weight: 700;
  color: var(--text);
}

.tag-note-card-desc {
  font-size: 0.875rem;
  color: var(--muted);
  line-height: 1.5;
}

.tag-note-card-arrow {
  font-size: 0.8125rem;
  font-weight: 700;
  color: var(--accent);
  margin-top: 4px;
}

.back-link {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-size: 0.8125rem;
  font-weight: 700;
  color: var(--muted);
  text-decoration: none;
  margin-bottom: 24px;
}

.back-link:hover {
  color: var(--accent);
  text-decoration: none;
}

.vendor-card {
  padding: 20px;
}

.vendor-card h2 {
  font-size: 1rem;
  font-weight: 800;
  margin-bottom: 8px;
}

.vendor-card p {
  font-size: 0.8125rem;
  color: var(--muted);
  line-height: 1.6;
}

.vendor-card dl {
  display: grid;
  gap: 6px;
  margin: 12px 0;
}

.vendor-card dl div {
  display: flex;
  gap: 8px;
  font-size: 0.75rem;
}

.vendor-card dt {
  min-width: 48px;
  font-weight: 800;
  color: var(--text);
}

.vendor-card dd {
  color: var(--muted);
}

.vendor-card > a {
  font-size: 0.8125rem;
  font-weight: 800;
}

.sources-page .article-header {
  margin-bottom: 40px;
}

.sources-page .callout {
  background: var(--accent-soft);
  border: 1px solid rgba(99, 102, 241, 0.2);
  border-radius: var(--radius-sm);
  padding: 14px 18px;
  margin: 0 0 40px;
  font-size: 0.8125rem;
  color: var(--muted);
  line-height: 1.6;
}

.sources-page .vendor-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 16px;
  margin-bottom: 48px;
}

.sources-page .vendor-card {
  display: flex;
  flex-direction: column;
  gap: 10px;
  padding: 22px 22px 18px;
  border-radius: var(--radius);
  transition: box-shadow 0.15s, border-color 0.15s;
}

.sources-page .vendor-card:hover {
  border-color: rgba(99, 102, 241, 0.35);
}

.sources-page .vendor-name {
  font-size: 1rem;
  font-weight: 800;
  color: var(--text);
}

.sources-page .vendor-desc {
  flex: 1;
  color: var(--muted);
  font-size: 0.8125rem;
  line-height: 1.6;
}

.sources-page .vendor-meta {
  display: flex;
  flex-direction: column;
  gap: 5px;
}

.sources-page .vendor-meta-row {
  display: flex;
  gap: 8px;
  color: var(--muted);
  font-size: 0.75rem;
}

.sources-page .vendor-meta-row strong {
  flex-shrink: 0;
  min-width: 60px;
  color: var(--text);
  font-weight: 700;
}

.sources-page .vendor-link {
  display: inline-block;
  margin-top: 6px;
  color: var(--accent);
  font-size: 0.8125rem;
  font-weight: 700;
  letter-spacing: 0.02em;
}

.sources-page .vendor-link:hover {
  color: var(--accent-dark);
}

.sources-page .price-cta {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 24px;
  flex-wrap: wrap;
  border: 1px solid var(--border);
  border-left: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 28px 32px;
  margin: 0 0 48px;
}

.sources-page .price-heading {
  margin-bottom: 4px;
  color: var(--text);
  font-size: 1.25rem;
  font-weight: 800;
}

.sources-page .price-note {
  font-size: 0.8125rem;
}

.sources-page .price-cta .btn-cta {
  flex: 0 0 auto;
  margin-top: 0;
  padding: 13px 28px;
  font-size: 0.9375rem;
  letter-spacing: 0.02em;
  white-space: nowrap;
}

.sources-page .disclaimer {
  margin: 0 0 48px;
}

.sources-page .content-section {
  margin: 0 0 48px;
}

.sources-page .content-section h2 {
  margin: 0 0 16px;
  padding-bottom: 10px;
  border-bottom: 1px solid var(--border);
  color: var(--text);
  font-size: 1.125rem;
  font-weight: 700;
}

.sources-page .related-links {
  display: flex;
  flex-direction: column;
  gap: 10px;
}

.sources-page .related-link {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  padding: 14px 18px;
  color: var(--text);
  font-size: 0.875rem;
  font-weight: 600;
}

.news-page .article-header {
  margin-bottom: 40px;
}

.eyebrow {
  margin-bottom: 10px;
  color: var(--accent);
  font-size: 0.75rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.article-list {
  display: flex;
  flex-direction: column;
  gap: 16px;
}

.article-card {
  display: block;
  padding: 24px 26px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
  color: var(--text);
  text-decoration: none;
  transition: box-shadow 0.15s, border-color 0.15s;
}

.article-card:hover {
  border-color: var(--accent);
  box-shadow: var(--shadow-hover);
  color: var(--text);
  text-decoration: none;
}

.article-card .card-meta {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 8px;
  color: var(--muted);
  font-size: 0.8125rem;
}

.article-card .card-tag {
  background: var(--accent-tag);
  border-radius: 4px;
  color: var(--accent);
  font-size: 0.6875rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  padding: 3px 8px;
  text-transform: uppercase;
}

.article-card h2 {
  margin: 0 0 8px;
  color: var(--text);
  font-size: 1.0625rem;
  font-weight: 700;
  line-height: 1.4;
}

.article-card p {
  margin: 0;
  color: var(--muted);
  font-size: 0.9rem;
  line-height: 1.6;
}

.article-card .read-more {
  display: inline-block;
  margin-top: 14px;
  color: var(--accent);
  font-size: 0.8125rem;
  font-weight: 600;
}

.article-card-with-image {
  display: grid;
  grid-template-columns: 190px minmax(0, 1fr);
  gap: 18px;
  align-items: stretch;
  padding: 18px;
}

.article-card-image {
  overflow: hidden;
  border-radius: var(--radius-sm);
  background: var(--surface2);
}

.article-card-image img {
  width: 100%;
  height: 100%;
  aspect-ratio: 3 / 2;
  min-height: 142px;
  object-fit: contain;
}

.article-card-content {
  min-width: 0;
}

.news-article .article-meta {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 12px;
  margin-bottom: 12px;
  color: var(--muted);
  font-size: 0.8125rem;
}

.news-article .article-meta .tag {
  border-radius: 4px;
  padding: 3px 8px;
  letter-spacing: 0.06em;
}

.article-hero-image {
  overflow: hidden;
  margin: 0 0 36px;
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
}

.article-hero-image img {
  width: 100%;
  aspect-ratio: 3 / 2;
  object-fit: cover;
}

.timeline,
.peptide-list-card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
  margin: 24px 0;
  padding: 22px 24px;
}

.timeline-label,
.peptide-list-card .plc-label,
.callout-label {
  margin-bottom: 16px;
  color: var(--accent);
  font-size: 0.6875rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.timeline-label {
  color: var(--muted);
}

.timeline-item {
  display: flex;
  gap: 14px;
  padding: 10px 0;
  border-bottom: 1px solid var(--border);
  font-size: 0.875rem;
}

.timeline-item:last-child,
.peptide-row:last-child {
  border-bottom: 0;
  padding-bottom: 0;
}

.timeline-date {
  flex-shrink: 0;
  min-width: 110px;
  color: var(--accent);
  font-weight: 700;
  white-space: nowrap;
}

.timeline-event {
  color: var(--text);
  line-height: 1.5;
}

.peptide-row {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 12px;
  padding: 9px 0;
  border-bottom: 1px solid var(--border);
  font-size: 0.875rem;
}

.peptide-name {
  color: var(--text);
  font-weight: 700;
}

.peptide-use {
  color: var(--muted);
  font-size: 0.8125rem;
  text-align: right;
}

.sources-section {
  margin-top: 48px;
  padding-top: 24px;
  border-top: 1px solid var(--border);
}

.sources-section h2 {
  margin-bottom: 16px;
  color: var(--text);
  font-size: 0.9375rem;
  font-weight: 700;
}

.sources-list {
  display: flex;
  flex-direction: column;
  gap: 10px;
  list-style: none;
  padding-left: 0 !important;
}

.sources-list li {
  color: var(--muted);
  font-size: 0.8125rem;
  line-height: 1.5;
}

.sources-list .src-num {
  margin-right: 6px;
  color: var(--text);
  font-weight: 700;
}

.start-page .article-header {
  margin-bottom: 48px;
}

.intro-note {
  background: var(--accent-soft);
  border: 1px solid rgba(99, 102, 241, 0.18);
  border-radius: var(--radius);
  padding: 22px 26px;
  margin-bottom: 40px;
  color: var(--text);
  font-size: 0.9375rem;
  line-height: 1.7;
}

.intro-note strong {
  color: var(--accent);
}

.section-label {
  margin: 48px 0 16px;
  color: var(--muted);
  font-size: 0.75rem;
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.section-label:first-of-type {
  margin-top: 0;
}

.guide-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(320px, 1fr));
  gap: 16px;
}

.guide-card {
  display: flex;
  flex-direction: column;
  gap: 10px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
  color: var(--text);
  padding: 24px 22px;
  text-decoration: none;
  transition: box-shadow 0.15s, border-color 0.15s;
}

.guide-card:hover {
  border-color: var(--accent);
  box-shadow: var(--shadow-hover);
  color: var(--text);
  text-decoration: none;
}

.guide-card .card-icon {
  color: var(--accent);
  font-size: 0.75rem;
  font-weight: 800;
  letter-spacing: 0.08em;
}

.guide-card h2 {
  color: var(--text);
  font-size: 1rem;
  font-weight: 700;
  line-height: 1.35;
}

.guide-card p {
  flex: 1;
  color: var(--muted);
  font-size: 0.875rem;
  line-height: 1.6;
}

.guide-card .read-more {
  margin-top: 4px;
  color: var(--accent);
  font-size: 0.8125rem;
  font-weight: 600;
}

.bridge-block {
  display: flex;
  align-items: flex-start;
  gap: 18px;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
  margin-top: 48px;
  padding: 24px 26px;
}

.bridge-icon {
  flex-shrink: 0;
  color: var(--accent);
  font-size: 0.75rem;
  font-weight: 800;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.bridge-block h3 {
  margin-bottom: 6px;
  color: var(--text);
  font-size: 1rem;
  font-weight: 700;
}

.bridge-block p {
  margin-bottom: 14px;
  color: var(--muted);
  font-size: 0.875rem;
  line-height: 1.6;
}

.btn-bridge {
  display: inline-block;
  background: var(--accent);
  border-radius: var(--radius-sm);
  color: #fff !important;
  font-size: 0.8125rem;
  font-weight: 700;
  padding: 8px 18px;
  text-decoration: none;
}

.btn-bridge:hover {
  background: var(--accent-dark);
  text-decoration: none;
}

.research-note .article-body {
  max-width: 680px;
}

.research-note .tag.fda {
  background: var(--approved-bg);
  color: var(--approved-text);
  border: 1px solid var(--approved-border);
}

.research-note .tag.fda:hover {
  background: var(--approved-text);
  color: #fff;
}

.research-note .approval-callout {
  background: var(--approved-bg);
  border: 1px solid var(--approved-border);
  border-radius: var(--radius);
  padding: 18px 22px;
  margin: 0 0 40px;
  font-size: 0.875rem;
  color: var(--approved-text);
  line-height: 1.6;
  box-shadow: none;
}

.research-note .approval-callout strong {
  display: block;
  margin-bottom: 6px;
  font-size: 0.8125rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.research-note .approval-callout ul {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 4px;
  margin: 0;
  padding-left: 0;
}

.research-note .approval-callout li {
  margin: 0;
}

.research-note .approval-callout li::before {
  content: "\2713  ";
  font-weight: 700;
}

.research-note .stats-bar {
  margin-bottom: 48px;
}

.research-note .stat-card {
  border-radius: var(--radius);
  padding: 16px 20px;
}

.research-note .stat-card strong {
  font-size: 1.125rem;
  font-weight: 700;
}

.research-note .stat-card small {
  margin-top: 2px;
}

.research-note .content-section,
.research-note .bibliography,
.research-note .related-section {
  margin: 0 0 48px;
}

.research-note .content-section h2,
.research-note .bibliography h2,
.research-note .related-section h2,
.research-note .section-heading {
  font-size: 1.125rem;
  font-weight: 700;
  color: var(--text);
  margin: 0 0 16px;
  padding-bottom: 10px;
  border-bottom: 1px solid var(--border);
}

.research-note .content-section p {
  color: var(--text);
  margin-bottom: 14px;
}

.research-note .content-section p:last-child {
  margin-bottom: 0;
}

.research-note .research-list {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 10px;
  margin: 0;
  padding-left: 0 !important;
}

.research-note .research-list li {
  background: var(--surface);
  border: 1px solid var(--border);
  border-left: 3px solid var(--accent);
  border-radius: var(--radius-sm);
  padding: 12px 16px;
  box-shadow: var(--shadow);
}

.research-note .research-list li strong {
  display: block;
  margin-bottom: 2px;
  font-size: 0.875rem;
  font-weight: 700;
  color: var(--text);
}

.research-note .research-list li span {
  font-size: 0.8125rem;
  line-height: 1.5;
  color: var(--muted);
}

.research-note .params-table-wrap {
  border: 1px solid var(--border);
  border-radius: var(--radius);
  overflow: hidden;
  box-shadow: var(--shadow);
  margin: 18px 0 24px;
}

.research-note .params-table {
  margin: 0;
  border: 0;
  border-radius: 0;
  box-shadow: none;
}

.research-note .params-table th {
  padding: 10px 14px;
  font-size: 0.6875rem;
  font-weight: 700;
  letter-spacing: 0.08em;
}

.research-note .params-table td {
  padding: 12px 14px;
}

.research-note .params-table td:first-child {
  width: 160px;
  color: var(--muted);
  font-weight: 600;
  white-space: nowrap;
}

.research-note .price-cta {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 24px;
  flex-wrap: wrap;
  border: 1px solid var(--border);
  border-left: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 28px 32px;
  margin: 0 0 48px;
  box-shadow: var(--shadow);
}

.research-note .price-cta .price-label {
  margin-bottom: 4px;
  font-size: 0.6875rem;
  font-weight: 700;
  letter-spacing: 0.08em;
}

.research-note .price-cta .price-range {
  font-size: 1.5rem;
  font-weight: 800;
}

.research-note .price-cta .price-note {
  margin-top: 4px;
  font-size: 0.8125rem;
}

.research-note .price-cta .btn-cta {
  flex: 0 0 auto;
  margin-top: 0;
  padding: 13px 28px;
  font-size: 0.9375rem;
  letter-spacing: 0.02em;
  white-space: nowrap;
}

.research-note .disclaimer {
  margin: 0 0 48px;
}

.research-note .cite {
  margin-left: 1px;
  padding: 0 1px;
  font-size: 0.65em;
  font-weight: 700;
  line-height: 0;
  vertical-align: super;
  text-decoration: none;
}

.research-note .bibliography .ref-list {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 10px;
  margin: 0;
  padding-left: 0 !important;
}

.research-note .bibliography .ref-list li {
  display: flex;
  gap: 12px;
  padding: 0;
  border: 0;
  border-radius: 0;
  background: transparent;
  box-shadow: none;
  color: var(--muted);
  font-size: 0.8125rem;
  line-height: 1.6;
  scroll-margin-top: 80px;
}

.research-note .bibliography .ref-num {
  flex: 0 0 auto;
  min-width: 24px;
  font-weight: 700;
  color: var(--accent);
}

.research-note .bibliography .ref-text {
  flex: 1;
  color: var(--muted);
}

.research-note .bibliography .ref-text em {
  font-style: italic;
}

.research-note .bibliography .ref-text a {
  color: var(--accent);
  font-size: 0.75rem;
  word-break: break-all;
}

.research-note .bibliography .ref-list li:target {
  margin: -8px -10px;
  padding: 8px 10px;
  border-radius: var(--radius-sm);
  background: var(--accent-soft);
}

@media (max-width: 600px) {
  .site-wrap { padding-inline: 20px; }
  .site-header {
    padding: 0 16px;
  }
  .site-header nav { gap: 14px; }
  .site-header nav a:not(.btn-launch) { display: none; }
  .stats-bar { grid-template-columns: 1fr; }
  .vendor-grid,
  .tag-grid {
    grid-template-columns: 1fr;
  }
  .note-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
  .peptide-index-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
  .price-cta {
    align-items: flex-start;
  }
  .research-note .price-cta {
    flex-direction: column;
    align-items: flex-start;
  }
  .research-note .stats-bar {
    grid-template-columns: 1fr 1fr;
  }
  .research-note .stats-bar .stat-card:last-child {
    grid-column: 1 / -1;
  }
  .timeline-item,
  .peptide-row,
  .bridge-block {
    flex-direction: column;
    gap: 4px;
  }
  .peptide-use {
    text-align: left;
  }
  .guide-grid {
    grid-template-columns: 1fr;
  }
  .article-card-with-image {
    grid-template-columns: 1fr;
  }
  .article-card-image img {
    height: 100%;
    aspect-ratio: 3 / 2;
  }
  .sources-page .vendor-grid {
    grid-template-columns: 1fr;
  }
  .sources-page .price-cta {
    flex-direction: column;
    align-items: flex-start;
  }
}